SpecificiT Pharma Inc. focuses on developing cellular therapies for hematological cancers that are currently untreatable with chimeric antigen receptor modified T cells (CAR-T) therapies. The company’s unique approach directs unmodified donor T-cells at Minor Histocompatibility Antigens (“MiHAs”) to safely eliminate cancer cells in patients. In addition, the company is employing a proprietary platform to discover novel tumor neoantigens that would allow this unique immunotherapy approach to be used against solid tumors.
next generation of health innovation companies.
Within every discovery born in laboratories across the country, lies the potential to treat, to heal, to save lives.
But the path from discovery to breakthrough takes immense investments of capital, resources, and expertise. That’s where Accel-Rx comes in.
As Canada’s health innovation accelerator, we give health science start-ups the support they need to turn promising therapeutic discoveries into life-changing treatments.
To identify, screen, and support—through capital and expertise—promising early-stage companies developing pharmaceuticals, medical devices, and diagnostics, so they can grow and scale to become the next generation of strong Canadian anchor companies in a globally competitive health sciences sector.
SoundBite Medical Solutions
Encycle is a biopharmaceutical company with a unique platform technology that enables the rapid synthesis of small drug-like macrocycles, called nacellins. Encycle’s nacellins provide orally bioavailable, non-biologic modulators, with enhanced permeability, allowing for drug absorption through the gut. This technology provides new therapeutic opportunities for previously underserved diseases and ailments, due to previous oral drug delivery complications. Encycle is concurrently screening their nacellin library for new targets of interest.
To find out more, visit encycletherapeutics.com
Flosonics is a medical device company focused on developing non-invasive sensors to improve the management of critically ill patients. Flosonics Medical’s flagship smart-bandage product, the FloPatch, addresses unmet clinical needs of critically ill patients and the physicians, nurses, and paramedics who care for them in the ambulance, emergency department, operating room, and intensive care unit.
ImStar Therapeutics is a biopharmaceutical company, developing a new approach to treat ALS (Amylotrophic Lateral Sclerosis), commonly known as Lou Gehrig’s disease. ALS is a progressive neurodegenerative disease that cuases muscle weakness, paralusis, and ultimately respiratory failure. 450,000 people have the condition and every 90 minutes someone is diagnosed with it. Most people with ALS live only 2-5 years after experiencing the first signs of the disease.
ImStar is developing treatments directed at a new proprietary target, TANA (TDP-43 associated NF-kB activation), in a key immune system activation pathway implicated in ALS. This proprietary target could lead to the future development of treatments for ALS as well as other neurodegenerative diseases such as Parkinson’s.
To find out more, visit imstartx.com
KalGene Pharmaceuticals is a pre-clinical stage company focused on the development of precision medicine therapeutics to slow the progression of Alzheimer’s disease. Kalgene Pharmaceutical’s lead, KAL-ABP, targeting toxic amyloid beta oligomers, has been shown in animal models of Alzheimer’s Disease to cross the blood-brain barrier and to significantly reduce the plaque burden, leading to improved cognition and neuronal connectivity.
KisoJi is a biotechnology company focused on creating best-in-class drugs based on this novel screening platforms in antibodies, stem cells, and cancer stem cells. Through this platform, KisoJi plans to create next generation antibodies that have unique anti-cancer mechanisms. Such therapeutic antibodies have the potential to treat a wide range of cancers with the potential for limited side effects compared to current treatments due to their differentiating properties.
A biotechnology company that develop innovative treatments for dermal scarring. Scar-X’s mission is to improve the lives of surgical patients worldwide by providing therapies that prevent and reduce the occurrence of disfiguring, uncomfortable, or cosmetically unattractive scars. Scar-X’s lead candidate, discovered by Dr. Alman, Senior Scientist and head of Orthopedic Surgery at SickKids, is the re-purposing of nefopam into a topical anti-scarring treatment.
SoundBite Medical Solutions
SoundBite Medical Solutions is developing a proprietary shockwave technology to address significant unmet clinical needs in interventional cardiovascular therapy. Through an elegant combination of hardware and software, it can, in a controlled manner, deliver high amplitude shockwave pulses through guidewires and other interventional tools, to specifically attack highly calcified and fibrotic tissue in the arterial vascular system, while leaving healthy, elastic vessel walls largely unharmed.
Zucara is developing the first drug therapy to prevent hypoglycemia in people with diabetes. The Company’s first-in-class therapeutic is focused on improving glucagon counterregulation by inhibiting somatostatin which is dysregulated in Type 1 diabetes. Preventing hypoglycemia would dramatically change diabetes disease management, improving both patient health and quality of life.
To find out more, visit zucara.ca
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What People Say
There has been great wealth generation in the life science sector in Canada over the years and organizations like Accel-Rx, along with a healthy venture capital community, are playing a significant role in ensuring that the sector continues to be an important value creator for Canadians.
As a health sciences focused accelerator, Accel-Rx plays a key role in bringing technologies, entrepreneurs & investors together to enable more efficient & successful company growth and development.
CTI Life Sciences Fund
The establishment of Accel-Rx as the first true life sciences accelerator in Canada provides real value to the angel investor community, particularly as an accelerator with an accompanying seed matching fund opportunity.
Founder, E-Fund (Angel Fund) Co-Manager,
VANTEC Angel Network
A central part of Canada's biotech ecosystem, Accel-Rx provides the highly-strategic & impactful foundational investment necessary for the advancement of innovation, company development, and overall growth of Canada’s biotech sector. All told, Accel-Rx is a key player in making Canada a global life sciences leader which will generate significant economic & societal benefits for the country more broadly.
President & CEO,
From my experiences as both an investor & entrepreneur, I believe Canada has long been in need of an accelerator for life sciences companies similar to those that exist for other sectors.
President & Chief Executive Officer,
Indel Therapeutics Inc.
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